| Charles SALYER (1667-1740) | & | Rebecca BLOOMFIELD (1697-1770) |
| Daniel SANDERS (1767-1824) | & | Tamar WEEKS (1769-1852) |
| William Henry SANDERS (1775-1872) | & | Elizabeth DENNIS (1774-1850) |
| William Moses SANDERS (1774-1837) | & | Priscilla COKER (1784-1789) |
| Joseph SCOGGIN (1778-1854) | & | Lydia JAY (1780-1815) |
| Joseph SCOGGIN (1778-1854) | & | Martha Patsy GOODE (1780-????) |
| James Denton SCOTT (1818-1889) | & | Mary Elisabeth McINTOSH (1822-1896) |
| Joshua SEWELL (1755-1837) | & | Jennie WILLIS (1760-1834) |
| Samuel SEWELL (1715-1789) | & | Christian STOVER (1720-1775) |
| Samuel SEXTON (1771-????) | & | Kessiah GERMAN (????-????) |
| John SHEPHERD (1809-1879) | & | Margaret S. "Peggy" HAYES (1808-1893) |
| Adam SHERRILL (1697-1774) | & | Elizabeth CORZINE (1701-1769) |
| Daniel SHIPP (1750-1814) | & | Sarah (1754-1820) |
| Henry Ellis SHOAF (1849-1929) | & | Sarah Loretta MILLER (1853-1952) |
| Aaron SHORT (1718-1815) | & | Sarah Bird OLDHAM (1745-????) |
| John SIBLEY (1702-????) | & | Mary (????-????) |
| Robert SIBLEY (1728-1809) | & | Jerusha CHANDLER (1732-????) |
| John H. SKIPPER (1831-1902) | & | Emaline JOINER (1832-1867) |
| John H. SKIPPER (1831-1902) | & | Mary Jane HELMS (1833-????) |
| Abraham Washington SLAGLEY (1785-1901) | & | Emma WHIT (????-????) |
| Zachariah Benjamin SLAYER (1729-1798) | & | Elizabeth DUNN (1734-1800) |
| Bridgers SMELLEY (1801-1880) | & | Caroline MOTES (1795-1860) |
| Bridgers SMELLEY (1801-1880) | & | Clary PERKINS (????-1827) |
| Alexander SMITH (1747-1828) | & | Keziah LAMAR (1754-1838) |
| Harmon Savanah SMITH (1861-1937) | & | Mary Elizabeth FURCHES (1862-1942) |
| Mead A. SMITH (????-????) | & | Eliza (????-????) |
| Osborne Lewis SMITH (1889-1980) | & | Effie Lenoir PALMER (1889-1971) |
| William Martin SMITH (1824-1902) | & | Martha Ann MOORE (1840-1887) |
| William Osborne SMITH (1826-1876) | & | Rachel Melvina McMAHAN (1833-1899) |
| William S. SMITH (1826-1880) | & | Mary CATRON (1827-????) |
| Edward SMITHWICK (1750-????) | & | Dicey BENNETT (1750-????) |
| Calvin SPARKS (1808-????) | & | Susanna BRIDGES (1812-????) |
| David STEELE (1763-1812) | & | Elizabeth JETTON (1773-1849) |
| Isaac Milton STEELE (1805-????) | & | Jane HADLEY (1811-????) |
| Samuel McClellan STEWART (1825-1864) | & | Elizabeth Jane BRADSHAW (1833-1895) |
| John Edward "Ed" STOUT (1867-1937) | & | Ada Rebecca MOFFITT (1870-1933) |
| George STUMAN (1800-????) | & | Malinda VOYLES (1801-1880) |
| William SWALLOW (1785-1860) | & | Lydia WHEELER (1787-1860) |